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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
11.52
Human Site:
S664
Identified Species:
18.1
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S664
Q
V
L
K
G
M
T
S
E
S
D
S
I
G
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S664
Q
V
L
K
G
M
T
S
E
S
D
S
I
G
L
Dog
Lupus familis
XP_531814
1283
145094
V638
Y
V
P
L
D
S
D
V
V
S
A
T
R
P
G
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S663
L
K
G
M
T
S
E
S
D
S
V
G
L
T
P
Rat
Rattus norvegicus
XP_002726765
1361
151628
S666
L
K
A
M
T
S
E
S
D
S
V
G
L
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S770
S
V
I
K
S
L
T
S
E
S
D
S
L
G
L
Frog
Xenopus laevis
NP_001089247
1340
149481
T643
P
S
V
L
K
S
M
T
S
E
S
D
S
L
A
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
M663
L
P
P
A
L
K
A
M
T
P
E
C
D
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
P559
A
R
Y
Q
L
Y
V
P
P
D
Q
L
A
D
A
Honey Bee
Apis mellifera
XP_392346
1120
127429
E489
L
T
P
A
E
D
K
E
L
A
V
H
A
L
G
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
M555
T
I
Y
N
S
N
S
M
E
N
D
Q
K
K
E
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
E636
P
P
A
Q
V
L
F
E
R
G
K
L
L
P
K
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
N645
L
D
A
A
A
L
E
N
L
E
I
F
E
N
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
P637
G
D
G
S
S
F
L
P
K
M
L
S
E
L
A
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
Q611
E
Y
D
F
V
K
S
Q
H
S
M
V
L
D
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
13.3
N.A.
13.3
13.3
N.A.
N.A.
66.6
0
6.6
N.A.
0
0
13.3
0
P-Site Similarity:
100
N.A.
100
20
N.A.
26.6
26.6
N.A.
N.A.
86.6
13.3
13.3
N.A.
6.6
6.6
33.3
20
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
20
20
7
0
7
0
0
7
7
0
14
7
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
14
7
0
7
7
7
0
14
7
27
7
7
14
0
% D
% Glu:
7
0
0
0
7
0
20
14
27
14
7
0
14
0
7
% E
% Phe:
0
0
0
7
0
7
7
0
0
0
0
7
0
0
0
% F
% Gly:
7
0
14
0
14
0
0
0
0
7
0
14
0
20
20
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% H
% Ile:
0
7
7
0
0
0
0
0
0
0
7
0
14
0
0
% I
% Lys:
0
14
0
20
7
14
7
0
7
0
7
0
7
7
7
% K
% Leu:
34
0
14
14
14
20
7
0
14
0
7
14
34
20
27
% L
% Met:
0
0
0
14
0
14
7
14
0
7
7
0
0
0
0
% M
% Asn:
0
0
0
7
0
7
0
7
0
7
0
0
0
7
0
% N
% Pro:
14
14
20
0
0
0
0
14
7
7
0
0
0
14
14
% P
% Gln:
14
0
0
14
0
0
0
7
0
0
7
7
0
0
0
% Q
% Arg:
0
7
0
0
0
0
0
0
7
0
0
0
7
0
0
% R
% Ser:
7
7
0
7
20
27
14
34
7
47
7
27
7
0
7
% S
% Thr:
7
7
0
0
14
0
20
7
7
0
0
7
0
14
0
% T
% Val:
0
27
7
0
14
0
7
7
7
0
20
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
14
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _